Novel esters of �³-aminobutyric acid (GABA) with monocyclic terpenes were synthesized via\nSteglich esterification and characterized by 1H-NMR, IR and mass spectral studies. Their anticonvulsant,\nanalgesic and anti-inflammatory activities were evaluated by a PTZ-induced convulsion model,\nAITC-induced hyperalgesia and AITC-induced paw edema, respectively. All studied esters, as well\nas their parent terpenes, were found to produce antinociceptive effects in the AITC-induced model\nand attenuate acute pain more than the reference drug benzocaine after their topical application.\nGABA esters of L-menthol and thymol were also shown to exceed the reference drug ibuprofen\nin their ability to decrease the inflammatory state induced by intraplantar injection of the TRPA1\nactivator AITC. The present findings indicate that GABA esters of carvacrol and guaiacol are not a\nclassical prodrug and possess their own pharmacological activity. Prolonged antiseizure action of the\nester based on the amino acid and guaiacol (200 mg/kg) was revealed at 24 h after oral administration.\nFurthermore, orally co-administered gidazepam (1 mg/kg) and GABA esters of L-menthol, thymol\nand carvacrol produce synergistic seizure prevention effects.
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